MyBioSource.com's AKTIP Antibody (C-term) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, and Western Blot. The AKTIP Antibody (C-term) was generated using AKTIP, and Fts as the antigen and it reacts with Human, Mouse, Rat, and Non-Human Primate.
Description
The mouse homolog of this gene produces fused toes and
thymic hyperplasia in heterozygous mutant animals while homozygous
mutants die in early development. This gene may play a role in
apoptosis as these morphological abnormalities are caused by
altered patterns of programmed cell death. The protein encoded by
this gene is similar to the ubiquitin ligase domain of other
ubiquitin-conjugating enzymes but lacks the conserved cysteine
residue that enables those enzymes to conjugate ubiquitin to the
target protein. This protein interacts directly with
serine/threonine kinase protein kinase B (PKB)/Akt and modulates
PKB activity by enhancing the phosphorylation of PKB's regulatory
sites. Alternative splicing results in two transcript variants
encoding the same protein